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The RRP consists of a small fraction of total vesicles that are physically docked at the active zone, molecularly primed by active zone proteins (such as RIM and Munc13) into a SNARE-assembled, fusion-competent state (Kaeser and Regehr, 2017)

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However, these observations have not been reported in human primary islets

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The full Thymosin Beta-4 molecule, under the name RGN-259, has entered formal clinical trials for conditions including dry eye disease and cardiac recovery, which validates the underlying biological mechanism that TB-500 shares