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(iii) history of seizure disorder or gross neurological deficit

The best studied is GHK-Cu, the tripeptide glycyl-L-histidyl-L-lysine complexed with copper

[93] or the meta-analysis by Shi et al

A formulation of disulfiram in 2-hydroxypropyl--cyclodextrin and methylcellulose produced a delay in cataract formation in a recessive-type hereditary strain of cataractous rats by attenuating the increase in the nitric oxide and lipid peroxidation levels [105]

There is also increasing evidence that deregulation of GSH synthesis contributes to the pathogenesis of diseases such as diabetes mellitus, pulmonary and hepatic fibrosis, alcoholic liver disease, cholestatic liver injury, endotoxemia, and drug-resistant tumors cells [10]