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Accordingly, several gut metabolic dysfunctions could contribute to long-term neuro-cognitive impairments in PASC, including: (i) perturbed gut-brain axis due to loss of SCFA producing intestinal flora, which may cause neuropsychiatric disorders 728

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The formation of 5-methylTHF depends on N 5,10 -methylenetetrahydrofolate reductase (MTHFR), which catalyzes the reduction of N 5,10 -methylenetetrahydrofolate (5, 10-methyleneTHF) (Fig