Preclinical studies in rodents have demonstrated reductions in fat mass, improved insulin sensitivity, and increased metabolic rate without significant changes to food intake (Neelakantan et al., 2019)
These animals were housed under controlled environmental conditions and had free access to food and water [1]
When used appropriately under physician guidance as part of comprehensive metabolic optimization strategies, AOD-9604 may provide a research-based tool for individuals committed to evidence-informed approaches to body composition improvement
By blocking NNMT, it helps preserve NAD+, a vital coenzyme your cells need for energy production and DNA repair
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
