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Such a postulation has strong support based on the outcome from claudin-2 TG mice, which are resistant to colitis

Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery

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By combining HDACi with chemotherapy drugs, it may be possible to significantly improve patients quality of life and reduce the overall toxicity burden of chemotherapy without compromising antitumor efficacy (87)