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The ECM, composed of proteoglycans, collagen, and minerals, is essential for maintaining the biomechanical properties of articular cartilage

However, many organisms can survive without these enzymes and some organisms completely lack GR, suggesting that alternative mechanisms for regenerating GSSG may exist (Kanzok et al., 2001

[7] Such large doses are administered under direct medical supervision and via IV drip to ensure safety

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