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et al., 2023) the cAMP/PKA/p-CREB pathway was altered in the amygdala alongside neuronal apoptosis (Jiang et al., 2023), and cortical cytokinesincluding IL-1, IL-6, and TNF- were elevated (Wang J

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These findings show that, despite targeting similar receptors, psilocybin and lisuride diverge in their neurobiological pathways and behavioral outcomes, shedding light on the mechanisms distinguishing psychedelics from non-psychedelics