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Available from: MacFarquhar JK, Broussard DL, Melstrom P, Hutchinson R, Wolkin A, Martin C et al (2010) Acute selenium toxicity associated with a dietary supplement

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Eur J Immunol 32:286673, PMID: 12355439 Palomares T, Alonso-Varona A, Alvarez A, Castro B, Calle Y, Bilbao P (1997) Interleukin-2 increases intracellular glutathione levels and reverses the growth inhibiting effects of cyclophosphamide on B16 melanoma cells

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The ability to target anti-TNF-alpha activity to the intestine could help to thwart these drawbacks and would also allow for higher dosing and thus better disease control