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Johnson WM, Wilson-Delfosse AL, Mieyal JJ

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Amino acid metabolism in DKD exhibits paradoxical effects: while BCAAs activate mTORC1 signaling leading to insulin resistance and podocyte injury, sulfur amino acid-derived H 2 S confers renoprotection through Nrf2 activation, whereas homocysteine accumulation promotes vascular damage (Figure 3)

Xiao SQ, Cheng M, Wang L, Cao J, Fang L, Zhou XP, et al