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In IgG4 thyroiditis, increased fibrosis and lymphoid tissue cause a pale white color on the cut surfaces of the thyroid glands (Li et al

These are associated with matrix degradation and acceleration of degenerative changes in the discs

It is noteworthy to mention that neurons are particularly vulnerable to damage from hypoxia, which causes distinctive histolog- ical ischemic changes including pronounced cytoplasmic eosinophilia (red neurons), collapse of cytoplasm with accentuated pericellular spaces, and pyknotic nuclei with indistinct nucleoli

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