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An RDP multicenter study from 2008 showed that Pycnogenol supplementation significantly reduced abdominal discomfort in women with dysmenorrhea ( for two menstrual cycles, during which they needed significantly less analgesic medication than in the registration period of two months before supplementation (46%) and less than placebo controls (28%)

10.3233/JAD-2010-1221 38 NakamuraY

Efflux regulators also respond to endogenous ligands (eg, AcrR responds to polyamines) to induce acrAB-tolC

BioMed Pharmacother (2021) 138:111406

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