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However, CJC-1295 (especially the DAC version) can cause sustained elevation in IGF-1, whichif mismanagedmay increase the risk of: Insulin resistance Carpal tunnel syndrome Soft tissue growth (in rare, prolonged cases) Pituitary overstimulation That said, these issues are more often associated with excessive dosing or continuous high-frequency use

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Contraception Counseling : Women using oral hormonal contraceptives should use an additional non-hormonal contraceptive method for 4 weeks after initiating tirzepatide and for 4 weeks after each dose increase

As with all research peptides, the absence of long-term human safety data means dose, duration, and cycling decisions should be made with a licensed provider familiar with the published literature

R., DAlessio, D., Drucker, D