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Preclinical studies in animal models, such as EAE and DSS-induced colitis, have consistently demonstrated the efficacy of targeting metabolic nodes like mTOR, AMPK, HIF-1, and PKM2 in rebalancing Th17/Treg responses

Equally, the 12-g dose ingested was higher than that typically used in CM research, therefore the changes in plasma citrulline concentration following the most common 8 g dose are unknown

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