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Endothelial dysfunction has been demonstrated in vivo (306, 311), in the large vessels of ME/CFS patients (307, 311) through flow-mediated dilation (FMD) and in the microcirculation through post-occlusive reactive hyperaemia

Borges for their contribution to the peer review of this work

14,15 It has also been noted that endogenous GHK declines with age, with higher levels in young healthy people as compared to older adults around age 60