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Weihofen A, Liu Y, Arndt JW, Huy C, Quan C, Smith BA, Baeriswyl JL, Cavegn N, Senn L, Su L, Marsh G, Auluck PK, Montrasio F, Nitsch RM, Hirst WD, Cedarbaum JM, Pepinsky RB, Grimm J, Weinreb PH (2019) Development of an aggregate-selective, human-derived -synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinsons disease models

If a patient experiences side effects, the dose escalation is delayed

A common and easy-to-manage protocol is to add a volume that makes the math simple for future dosing

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In some embodiments, the otic formulation or composition comprises about 0.7% by weight of the poloxamer