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[18] These biosynthetic strategies for reducing the toxicity of pathogenic fungal strains that produce gliotoxin are still in their early stages of exploration but could provide novel methodologies for the adoption of therapeutic uses for gliotoxin

US, 2012

The assay for -glutamylcysteine synthetase activity is based on the formation of GSH from cysteine, glutamate and glycine in the presence of the excess of glutathione synthetase

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The p38 goes from the cytosol to the nucleus after activation, where they activate downstream transcriptional targets such as PAX6, ETS1, PRAK, MK3, RAR, AP-1, ATF1, and CHO to control cellular processes (144) It is generally believed that overactivation of the MAPK/ERK signaling pathway is positively related to chemoresistance