ghk-cu copper taste side effect PSA] Finally, a Dr. explains the mechanism behind the "copper uglies" : r/SkincareAddiction What Are the Copper Uglies?

By dementia we mean a serious loss of cognitive ability in a previously unimpaired person, beyond what might be expected from normal aging

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Glycemic Control and Incretin Physiology GLP1R and GIPR stimulation are studied for glucosedependent insulinotropic activity and postprandial glycemic modulation

A 2023 phase II trial in 40 post-surgical patients found 0.5% GHK-Cu gel reduced scar volume by 35% at 3 months versus silicone (p=0.002) (Hosokawa et al., 2023)

They added GHK-Cu in concentrations of 10 M to 10 M and measured: Collagen synthesis (by radioactive proline incorporation) Non-collagen protein synthesis Cell proliferation What they found: Stimulation of collagen synthesis by 70 % at the optimal concentration of 10 M (1 nM) The effect was NOT dependent on increased proliferation, fibroblasts increased production per cell Background: GHK without copper had a dramatically weaker effect , Cu is critical Reversibility: After removing GHK-Cu, synthesis returned to baseline Why it matters: This is the fundamental mechanistic study that documented the effect of GHK-Cu on collagen