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Funding The author(s) declare that financial support was received for the research and/or publication of this article

Balancing the Whole System Your body uses B12, folate, and B6 together in whats called the methionine cycle

The next category groups together hospitals considered urban or rural, in terms of whether they receive the IME adjustment, the DSH adjustment, both, or neither

Notably, hypermetabolism and increased FGF-21 are frequently associated with mitochondrial disorders [57, 58] and recent studies have shown that FGF-21 can modulate mitochondrial bioenergetics and dynamics by inhibiting mitochondrial fission and oxidative stress [53, 59]