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The high water content (90 to 92 percent) activates stretch receptors in the stomach, signaling satiety long before you have consumed many calories

Gravdal et al., 2023)

You inject subcutaneously, meaning into the fat layer just under the skin, usually on the lower abdomen about an inch or two from the belly button

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This failure mode is most common when vials are stored above 8C, subjected to freeze-thaw cycles, or punctured with non-sterile needles