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35 In a rabbit model of osteoarthritis, intra-articular injection of AOD-9604 combined with hyaluronic acid (HA) demonstrated improvements in cartilage morphology and joint surface integrity

Vitamin B12 is necessary for patients with a low serum level of vitamin B12 because they take particular medications or because they suffer from pernicious anemia, gastrointestinal or autoimmune disorders, or alcoholism

Seven of these trials are expected to report results in 2026

We also thank the Biomedical Research Unit and Biomedical Research Core of Tohoku University Hospital and Biomedical Research Core of Tohoku University Graduate School of Medicine for technical support

Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or if you have a liver disease or diabetes