metastatic melanotic sarcoma Clear-Cell With an Unusual Presentation Mimicking Melanoma Pulmonary metastatic melanoma: current state

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Notably, in TMZ-resistant LN229 cells, metformin suppressed key proteins, including mitochondrial transcription factor A, Twist, and O-6-methylguanine-DNA methyltransferase (MGMT) ( In summary, metformin disrupts the normal proliferation process of glioma cells and triggers apoptosis by activating the AMPK/mTOR signaling pathway, cell cycle arrest, mitochondria-dependent apoptosis pathway, inhibition of tumor cell metabolism, oxidative stress, and DNA damage, which provides a new idea for the treatment of glioma

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