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Several critical questions remain unresolved: (1) most existing studies are confined to animal and cellular models, with a notable lack of large-scale population-based investigations and clinical validation, thereby impeding translational application

Similar results were obtained by Baeza et al., who demonstrated that pure caffeine, unlike CGAs, does not provide significant protection against OS [107]

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Oral rehydration solutions or drinks containing balanced electrolytes help replace sodium and potassium lost during the inflammatory process