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Diagnosis is established through history, with ongoing efforts in translational research to establish the earlier diagnosis.Tau protein plays an important role in the stabilization of microtubules and converts 6S dimers of tubulin into the 36s rings required for microtubule polymerization, resulting in localization at axons of neurons under normal physiological conditions ( Tau protein affects cell-cycle regulation by plasma-membrane interaction and tyrosine kinase ( A laboratory study conducted on transgenic mice expressing human non-mutant tau was used to assess the impact of the post-translational hyper-phosphorylation of tau on the central and peripheral nervous system after a period of 3 and 6 months ( PET imaging studies on Alzheimers disease have shown that cognition has a better correlation with tau pathology than with A-plaque deposition ( Small-fiber neuropathy & long COVID Small-fiber neuropathy is an umbrella term for neuropathies affecting thinly A-myelinated and un-myelinated C-fibers