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Reviews of the rodent work note that the mechanism doesnt involve the hormonal suppression or receptor desensitization that would predict tolerance or rebound, and that adipose SAM levels tend to normalize rather than crash under inhibition

Kalaras, postdoctoral assistant in food sciences

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Altogether, these findings suggest a potential beneficial effect of vitamin B12 in reducing neuroinflammation and promoting neuroprotection in patients with persistent VCD long after experiencing mild acute COVID-19