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For a standard 8mm insulin needle, the entire length should be in tissue

Epitope-Specific Immunotherapy Targeting CD4-Positive T Cells in Celiac Disease: Safety, Pharmacokinetics, and Effects on Intestinal Histology and Plasma Cytokines with Escalating Dose Regimens of Nexvax2 in a Randomized, Double-Blind, Placebo-Controlled Phase 1 Study

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Its mechanism suggests potential benefit, but without validated dosing protocols or safety data in ischemic models, using it as a primary intervention introduces unquantified risk and reduces study reproducibility