Eaton-Fitch N, Du Preez S, Cabanas H, Muraki K, Staines D, Marshall-Gradisnik S
Procedures were in line with the standard operating procedures (SOPs) of the Animal Pharmacology Facility, and the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (ETS 123)
Theoretical concern of sulfur sensitization with very high doses
Co-lyophilization in a predefined 1:1 ratio delivers both mechanisms in a single vial, reducing preparation variability and minimizing measurement errors associated with manual dual-peptide preparation
Moving release farther down the intestinal tract changes the pH, enzymes, transit conditions, mucus layer, surface area, and local concentration around the formulation