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Moreover, gut microbial alterations, such as enrichment of Enterorhabdus , are associated with elevated plasma TMAO levels, leading to exacerbated renal fibrosis and functional decline through activation of oxidative stress and inflammatory pathways ( Figure 4 ) [169]

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Comp Biochem Physiol 116B:217221 Carney Almroth B, Albertsson E, Sturve J, Frlin L (2008) Oxidative stress, evident in antioxidant defences and damage products, in rainbow trout caged outside a sewage treatment plant