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HPXRs play an important role in macrophage function in the immune system because heme from 59 FehemeHPX was efficiently incorporated into myeloperoxidase, a heme-protein in differentiated HL-60 cells (Vestal et al., 1990) and into cytochrome P-450 apo-protein ( 3.1 Isolation and identification of hemeHPX binding proteins in human HL-60 cells The HPX-binding scavenger receptor LRP1 is expressed by certain human immune cells, e.g