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Chronic hypersecretion of GH into the circulation, usually from a GH-secreting pituitary adenoma, is classically associated with acromegaly, a debilitating disease characterized by excessive skeletal growth, soft tissue enlargement, insulin resistance, and cardiovascular and gastrointestinal morbidities

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The GIP receptor activation adds an additional metabolic dimension that appears to enhance fat oxidation and improve insulin sensitivity beyond what GLP-1 activation alone achieves