While hGH doesnt directly increase testosterone levels, some studies suggest that it may indirectly affect testosterone by stimulating the release of hormones that regulate testosterone production, says hormone specialist James R
For example, studies have shown that long-term ethanol exposure can downregulate the expression of serotonin receptors, particularly the 5-HT1A and 5-HT2A receptors (Dahchour and Ward 2024)
Related research context GHK-Cu is part of the regenerative peptide and extracellular matrix (ECM) remodeling research class, commonly studied in models involving collagen synthesis, tissue regeneration, and metalloproteinase regulation
The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4
doi: 10.1016/S0026-0495(99)90013-6 39 AlesciSManoliICostelloRCoatesPGoldPWChrousosGPet al
