(PubMed) Lodge JK, Youn HD, Handelman GJ, et al
39, 405407 doi: 10.1016/j.healun.2020.03.012 63 SmartL.FawkesN
Disruption in iron homeostasis, including increased transferrin receptor expression and ferritin degradation via NCOA4-mediated ferritinophagy, contributes to ferroptotic susceptibility ( Lipid Peroxidation: Polyunsaturated fatty acids (PUFAs), especially arachidonic and adrenic acids, are substrates for lipoxygenases (LOX), which drive peroxidation in membrane phospholipids, generating cytotoxic lipid peroxides such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) ( Glutathione Depletion and GPX4 Inactivation: System Xc imports cystine for GSH synthesis
Replenishing glutathione supports the functional capacity of immune cells that depend on adequate intracellular redox status to operate effectively
Chrestensen CA, Starke DW, Mieyal JJ