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In a phase 3 trial involving adults with overweight or obesity (BMI 28 kg/m, or 24 kg/m with at least one weight-related comorbidity) without diabetes, treatment with 2.4 mg ecnoglutide produced a mean body weight reduction of 13.2% at 40 weeks

The increased OCR and upregulation of oxidative phosphorylation complexes further support melatonins role in enhancing mitochondrial function and energy metabolism in HGL5 cells

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Some proteins increased in both fractions, - -Enolase is a glycolytic protein that also rapidly increases and dimerizes at the surface of activated monocytes to form a plasminogen receptor critical for immune cell recruitment to the lung [26]

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