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The AD-associated APOE4 allele has been reported to enhance lactate synthesis, thereby altering the metabolic milieu, and to sensitize astrocytes to inflammatory stimuli without overtly changing baseline transcriptomic profiles

The penta-mutant ZJ12345 was constructed successfully, and the production of GSH was 19.10 mM in fed-batch fermentation, which was 1.33-fold the production of MG1655 expressing the same gene

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Acknowledgements We are grateful to the stroke patients for their participation in the research and to the staff from the ISTBI, Huashan Hospital, and National Clinical Research Center for Geriatric Diseases in the clinic study