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Therefore, it has multiple and diversified actions with immediate (endogenous melatonin, during the night) or prospective effects (exogenous melatonin, during the previous day)

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Given the brains unique susceptibility to proteotoxic stress, owing to its post-mitotic neuronal population, high metabolic demand, and reliance on precise proteome regulation, UPS integrity is indispensable for neuronal survival

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When you have an imbalance between these free radicals, toxins and antioxidants in your body, you have an increase in oxidative stress