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10.1016/j.ejphar.2016.09.005 22 CalviA.FischettiI.VerziccoI.MurriM

Hypothesized Complementary and Synergistic Dynamics Because CJC-1295 is believed to act via the GHRH receptor pathwaystimulating somatotroph cells in the pituitary to synthesize and secrete GH with prolonged actionand Ipamorelin is thought to act via GHS receptors (ghrelin receptor family) with more rapid but shorter-duration GH release, there is a strong theoretical basis for their combination to yield both sustained baseline elevation and augmented pulses of GH secretion

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