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i Also, it has been reported that acetaminophen poisoning is involved in nearly 50% of patients in the U.S

Pre-existing conditions can change the risk-benefit calculation

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Booth, W.T

Inhibitors targeting the enzymatic activity of P450, such as 4-methylpyrazole (Fomepizole), are evaluated in vitro and in vivo as possible alternative treatments for APAP induced liver injury (Kang et al., 2020