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Both pathways are linked in some cell types by the cleavage of BID, a proapoptotic member of the Bcl-2 family of proteins, generating tBID in a process catalyzed by caspase-8 activated by the extrinsic pathways (Scaffidi et al., 1998)

Ethics statement The animal study was reviewed and approved, and all experimental work was executed in accordance with the guiding principles of the Institute of Laboratory Animal Resources, Commission on Life Sciences University, National Research Council (1996), accepted through the Ethical Committee of Riphah Institute of Pharmaceutical Sciences (Ref

Opposing roles of Type I interferons in cancer immunity