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The ROS-mediated damage is further enhanced in older individuals since during aging, GSH levels appear to diminish in numerous tissues, thereby placing cells at increased risk of stress-related death (Maher, 2005)

Hence the use of HGF blockers could be used either prophylactically, or as a treatment to slow down the progression of the disease and subsequent loss of vision

This may cause insufficient blood to reach the brain

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As a narrative review, quantitative synthesis was not performed, and the potential for publication bias and study heterogeneity may limit the generalizability of the conclusions