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Adaptogenic herbs affecting all these issues simultaneously by a pleiotropic mechanism might be a much better strategy to treat dementia compared with the monospecific approaches of the past decades, most of which, if not all, have entirely failed

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Subsequent examination of membranous GLUT1 expression in both tissues revealed that TXNIP overexpression led to a significant decrease of GLUT1 expression in the ileum and colon after metformin treatment, where metformin increased GLUT1 expression (Fig