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At concentrations of 1 pM1 nM, DSIP stimulated calcium-dependent release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro suggesting any antinociceptive effects observed in animal models may be mediated through endogenous opioid peptide release rather than direct receptor binding [7]

& Calis, K

Reported Research Benefits Preclinical studies target muscle recovery, tendon and ligament repair, wound healing, anti-aging skin therapies, neuroprotection, angiogenesis promotion, and immunomodulation

Statistics Differences among the time points were evaluated using one-way analysis of variance (ANOVA) followed by Turkeys test using GraphPad Prism 6 (GraphPad Software, San Diego, CA, USA)