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Safety Assessment Acute toxicity A single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice

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Use-level and cost considerations The four peptides have substantially different per-mg pricing and therefore different finished-product cost contributions at typical use levels: Matrixyl at 5% use level in a finished serum represents about $5-15 of peptide cost per 30 mL bottle (depending on volume procurement scale) Snap-8 at 7% use level: about $2-8 per 30 mL bottle GHK-Cu at 1% use level: about $0.50-2 per 30 mL bottle (lowest per-finished-unit because the use level is much lower) AHK-Cu at 0.5% use level: about $0.30-1.50 per 30 mL bottle For premium-positioned multi-active products, brands typically combine GHK-Cu + Matrixyl + Snap-8 in a single formulation

Dangerous dietary supplements: Garcinia cambogia -associated hepatic failure requiring transplantation