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Sebro, R., OBrien, L., Torriani, M

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5.2 Ferroptosis of macrophage promotes atherosclerosis Macrophage death exhibits a dual role in atherogenesis

A study of patients with pancreatic cancer and gastrointestinal tumors reported that during omega-3 supplementation prior to chemotherapy, patients gained an average of approximately 2.5 kilograms of body weight, which was maintained after chemotherapy was initiated ( 3.4 Anticancer mechanisms of phytosterols and alkaloids 3.4.1 Interference with cholesterol metabolism and tumor cell membrane structure Phytosterols such as -sitosterol are structurally similar to cholesterol and competitively interfere with cholesterol utilization by tumor cells ( 3.4.2 Induction of apoptosis and inhibition of cancer cell proliferation Both -sitosterol and berberine inhibit cancer cell proliferation by inducing apoptosis through the mitochondria-mediated intrinsic pathway and blocking cell cycle progression ( 3.4.3 Influencing cancer-associated inflammation and immune escape -Sitosterol and berberine may also exert anticancer effects by modulating inflammatory mediators and immune responses in the tumor microenvironment ( 2 in tumor tissues, blocking the promotion of tumor cell proliferation by the COX-2/PGE 2 inflammatory axis (92)

J Clin Oncol Off J Am Soc Clin Oncol