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Freezing causes ice crystal formation that physically disrupts peptide chains

Keep vials in a dark environment UV light catalyzes oxidation of sensitive amino acids, particularly tryptophan and methionine residues

Agnihotri S, Burrell KE, Wolf A, Jalali S, Hawkins C, Rutka JT, et al

Compartment syndrome can develop at injection sites in leg muscles, causing numbness, blood clots and muscle spasms that result in permanent loss of function