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By silencing NNMT, it enables a natural uptick in NAD levels, leading to enhanced mitochondrial function, lean mass preservation, and fat metabolism without overstimulation

Acts peripherally, meaning it targets fat cells directly rather than influencing central appetite or hormonal pathways

This decrease was more pronounced when adipocytes from HSL-null mice were utilized, a finding that suggests cooperativity exists between the two enzymes, and indeed, a synergistic effect has been observed on lipolysis when cells are cotransfected with both desnutrin/ATGL and HSL (144)

This compares to approximately 23% weight loss with diet and exercise alone

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