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[14] As a result, the city reached its maximum size by the late 1970s and early 1980s

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Accordingly, several in vitro , pre-clinical and clinical studies have reported low immunogenicity, anti-inflammatory, anti-bacterial, anti-oxidative, and anti-scarring properties of placental-derived materials in different skin wound healing models, and 28 decellularized or devitalized placental matrices are currently FDA approved for clinical use as wound dressings (Kim et al., 2015

Ongoing low-dose exposure prevents full immune resolution, lowers physiological resilience, and increases vulnerability to secondary stressors