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Beyond its vital role as a coenzyme in energy metabolism, the important role of NAD + has expanded to be a co-substrate for various enzymes including sirtuins, PARPs, CD157, CD73, CD38 and SARM1

doi: 10.1016/j.phymed.2022.154182 235 MarkowitschSDSchuppPLaucknerJVakhrushevaOSladeKSMagerRet al

BijkerkCJMurisJWKnottnerusJAHoesAWde WitNJ

Gweyer, Wragg, Wilson

But the question that started it all was always the same: how do you help the human body do more of what it's already designed to do, without introducing anything foreign