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Gropper SS, Smith JL, Groff JL

By increasing extracellular glycine levels, GlyT1 inhibitors can enhance NMDAR function in a regulated manner, thereby improving physiological receptor signaling and synaptic plasticity while potentially avoiding excessive receptor overstimulation

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In one diabetic rat study, antioxidant activity increased, with rises in superoxide dismutase, glutathione peroxidase, and catalase, alongside reductions in oxidative stress markers such as malondialdehyde and reactive oxygen species