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10.3748/wjg.v22.i26.6036 [DOI] [PMC free article] [PubMed] [Google Scholar] 171.Shi M, Zhang Z, Xu R, Lin H, Fu J, Zou Z, et al

doi: 10.1038/nri3520 99 ChristABekkeringSLatzERiksenNP

It was found that the change in platelet count could be partially explained (adjusted R 2 = 0.41, p = 0.02), with the major factors being Tl (p = 0.002), As (p = 0.01), Cd (p = 0.03), and change in glutathione (p = 0.04)

Folic acid fortification, folate status and plasma homocysteine

The main factors that are generally associated with elevations of homocysteine are nutritional deficiency, particularly related to folate metabolism, mutations of the enzymes MTHFR and CBS (Aguilar)