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In our own work, we demonstrated significantly elevated TSPO binding in mood circuitry (anterior cingulate and prefrontal cortex and hippocampus) of unmedicated individuals with moderate-to-severe depression, with the largest increases observed in those reporting suicidal ideation [279]

Long-term prevention includes: Identifying and correcting root causes (e.g., hypothyroidism, adhesions, poor motility) Using prokinetics for at least 36 months after treatment Maintaining a balanced diet without excess sugar or fermentable carbs Supporting digestive function with Digestive Enzymes Ongoing gut-healing support (e.g., BPC-157, Curcumin Complex) In recurrent or refractory cases, further testing for mold toxicity, Lyme disease, H

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Fan et al 98 have reported that the GSTO2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men