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However, a randomized, double-blind Phase 2 trial of a single intra-articular dose of UBX0101 in 183 patients failed to improve knee pain and function [19], and concerns have arisen regarding the specificity, safety, and tolerability of the systemic use of senolytics [20,21,22]

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Supplementary Material Acknowledgments We thank the Siddhi Memorial Foundation in Bhaktapur for providing excellent facilities to undertake this study

(September 2024)